Abstract:
After 70 years since the zika was identified in Uganda, zika is now documented in 62 countries. In general, people
infected with this disease do not experience severe conditions, but for pregnant women can cause serious problems because the
zika can spread to the fetus. One result, zika can cause abnormalities in the fetal brain called microcephaly. Control and prevention
are very important to reduce the spread of this disease. Here, we discussed the problem of optimal control in the model of zika
transmission associated with the use of insecticide-treated nets (ITN) and indoor residual spraying (IRS). Using the approach of
optimal control theory, we completed the objective function so that the infected population and its control cost are minimum.
Numerically using the Forward-Backward Sweep Method, we obtained the control design of ITN and IRS as a function of time.
The results show that the use of both simultaneously is more effective in reducing the population of infection than the use of ITN
alone or the IRS alone.
